| Robert Downey Jr. | Sherlock Holmes |
| Jude Law | Dr. John Watson |
| Rachel McAdams | Irene Adler |
| Mark Strong | Lord Blackwood |
| Eddie Marsan | Inspector Lestrade |
| Robert Maillet | Dredger |
| Geraldine James | Mrs. Hudson |
| Kelly Reilly | Mary Morstan |
| William Houston | Constable Clark |
| Hans Matheson | Lord Coward |
| Regisseur | Guy Ritchie |
| Producent | Bruce Berman; Steve Clark-Hall |
| Schrijver | Michael Robert Johnson; Anthony Peckham |
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