| Sam Worthington | Perseus |
| Liam Neeson | Zeus |
| Ralph Fiennes | Hades |
| Jason Flemyng | Calibos / Acrisius |
| Gemma Arterton | Io |
| Alexa Davalos | Andromeda |
| Tine Stapelfeldt | Danae |
| Mads Mikkelsen | Draco |
| Luke Evans | Apollo |
| Izabella Miko | Athena |
| Regisseur | Louis Leterrier |
| Producent | Kevin De La Noy; William Fay |
| Schrijver | Travis Beacham; Phil Hay |
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